Journal Information
Download PDF
More article options
Clinical Research
DOI: 10.1016/j.bjane.2021.02.040
Open Access
Available online 29 March 2021
Impact of age on the incidence of complications after liver transplantation: A single-center retrospective study
Ju Yeon Parka,b, Yoon Ji Choic,
Corresponding author

Corresponding author.
, Hyun-Su Rid, Jung Min Leec, Hyo Jung Sone, Yoon Sook Leec, Je ho Ryuf, Kwang Ho Yangf
a Daedong Hospital, Department of Anesthesiology and Pain Medicine, Busan, Republic of Korea
b Pusan National University Yangsan Hospital, Research Institute for Convergence of Biomedical Science and Technology, Yangsan, Republic of Korea
c Korea University Ansan Hospital, Department of Anesthesia and Pain Medicine, Ansan, Korea
d Pusan National University Yangsan Hospital, Department of Anesthesia and Pain Medicine, Yangsan, Republic of Korea
e National Police Hospital, Department of Anesthesiology and Pain Medicine, Seoul, Korea
f Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Yangsan, Republic of Korea
Received 08 March 2019. Accepted 06 February 2021
Article information
Full Text
Download PDF
Figures (2)
Tables (5)
Table 1. Patients’ characteristics.
Table 2. Perioperative laboratory data in patients undergoing liver transplantation.
Table 3. Patients’ perioperative factors.
Table 4. Postoperative data of patients undergoing liver transplantation.
Table 5. Logistic Regression Analysis for death after liver transplantation.
Show moreShow less
Background and objective

Advances in surgical technique, postoperative management, and immunosuppressive therapy have led to a steady increase in the number of patients undergoing organ transplantation. This study aimed to compare the incidence of postoperative complications between young and elderly patients undergoing liver transplantation (LT) at a single university hospital.


The medical records of 253 patients who underwent LT between January 2010 and July 2017 were retrospectively reviewed. The patients were divided into two groups: those younger than 65 years (group Y, n=231) and those older than 65 years (group O, n=22). Data on patient demographics, perioperative management, and postoperative complications were collected.


The patients’ baseline characteristics, including underlying diseases and the Model for End-Stage Liver Disease scores, were not different between groups. Preoperative laboratory findings were not significantly different between the two groups, except for hemoglobin level. The total amounts of infused fluid and packed red blood cells were higher in group O than in group Y. The postoperative plasma creatinine level was higher in group O than in group Y; however, the incidence of postoperative complications was not considerably different between the two groups. In addition, there was no difference in the survival rate after LT depending on age.


With the development of medical technology, LT in elderly patients is not an operation to be avoided, and the prognosis is expected to improve. Therefore, continuous efforts to understand the disease characteristics and physical differences in elderly patients who require LT are essential.

Liver transplantation
Postoperative complications
Full Text

Liver transplantation (LT) has been recognized as the standard treatment for patients with end-stage liver disease based on accumulated experience and improvements in long-term outcome.1 The prolongation of life span has increased the number of patients waiting for organ transplantation, and the median age of liver transplant recipients has also increased owing to advances in surgical technique, intensive care, postoperative surgical treatment, and immunosuppressive therapy.2,3 However, the reported outcomes among elderly liver transplant recipients have varied widely. An early study from a single center reported a longer hospital stay and lower survival rate in patients aged > 60 years.4 The causes of high mortality were as follows: comorbidities before surgery, malignancy, cardiovascular and/or neurological disease after LT, increased risk of infection, increased resource utilization, and lower life expectancy.5,6 Consequently, most of the recently published studies showed similar outcomes in elderly recipients compared with younger recipients, with elderly patients showing a significantly lower incidence of acute rejection but higher incidences of infection and cancer.7–10 Advanced age alone is not a cause of transplant rejection; however, several studies have shown that the risk of complications is higher in elderly liver transplant recipients because of their high physiological age, functional status, and preoperative comorbidities.11

Although the number of candidates for LT has increased, organ availability does not fully meet the demand. Therefore, proper organ allocation and utilization are necessary, and it is important to determine whether there would be any difference in the risk of complications and outcomes after LT in elderly patients compared with younger patients. To clarify this issue, we aimed to evaluate the relationship between age and the risk of post-LT complications and to identify the important factors for safely performing LT in elderly patients.


This study was approved by the institutional review board (n. 2017–156). The medical records of patients who underwent LT from January 1, 2010 to July 31, 2017 were computer-searched, and data from 360 patients were collected (Figure 1).

Figure 1.

Flow diagram of the study.


A total of 253 patients were ultimately included in the study, after excluding 107 patients because of cerebral disease that could affect mental status, missing data about mental status after LT, retransplantation, or additional surgery.

The patient records were reviewed retrospectively, including hospitalization records, progress reports, consultation records, preoperative evaluation reports, anesthesia records, intensive care unit (ICU) records, nursing records, and discharge records. A preoperative examination was performed within 1 day before surgery, and postoperative tests were carried out within 1 day after transfer to the ICU.

Postoperative complications after surgery and before discharge were assessed by referring to the discharge records. Cardiac complications were defined as cardiac-related diseases such as angina and arrhythmia that needed treatment. Respiratory complications were defined as respiratory infections such as pneumonia that required management. Neurological complications included neurological problems such as cerebral hemorrhage that required treatment. The incidence of delirium was assessed in cases in which delirium was diagnosed in patients under psychiatric consultation and needed medical treatment with haloperidol or other drugs for delirium. In accordance with the Acute Kidney Injury Network (AKIN) criteria,12 patients with postoperative acute kidney injury were diagnosed. The infection rate was reviewed in cases with surgical site infection and sepsis. Acute rejection after LT was confirmed by pathologic biopsy results within 6 months after transplantation. Mortality was also evaluated in cases of deaths in the postoperative period before discharge.

Induction of anesthesia was performed with propofol and rocuronium or cisatracurium. Inhalation anesthesia was applied with sevoflurane or desflurane in an oxygen/air mixture with 40–50% inspired oxygen. Remifentanil (range 0.5–1μ−1.min−1) and a neuromuscular blocking agent (rocuronium [range 0.3–−1.h−1] or cisatracurium [range 0.1–−1.h−1]) were continuously infused. All patients underwent standard anesthetic monitoring, including electrocardiography and end-tidal carbon dioxide concentration, bispectral index, peripheral oxygen saturation, cerebral oxygenation using INVOS 5100C (COVIDIEN, Mansfield, MA, USA), and invasive arterial blood pressure monitoring in the radial and femoral arteries. An oxygen monitoring central venous catheter (PreSep; Edwards Lifesciences, Irvine, CA, USA) was inserted and used to evaluate circulation using an EV1000 platform (Edwards Lifesciences) for monitoring cardiac output, cardiac index, stroke volume, stroke volume index, central venous oxygen saturation, and systemic vascular resistance. Transfusion was performed to maintain the hematocrit level at 25–30%. Norepinephrine (0.01–0.4μ−1.min−1) was used to maintain adequate blood pressure during surgery (systolic blood pressure>90mmHg, mean arterial pressure>60mmHg). If norepinephrine was not effective, dobutamine, vasopressin, and epinephrine were used, depending on the condition of the patient.

Data were analyzed using SAS (Statistical Analysis System version 9.3; SAS Institute, USA) and R software version 3.3.2 (R Project for Statistical Computing, Austria). All data are presented as the mean±standard deviation, median (25th–75th percentile), or number of patients (%). The normality test was performed with the Shapiro-Wilk W-test or the Kolmogorov-Smirnov test. The independent t-test or Wilcoxon rank-sum test was used for continuous variables for comparison between the two groups. The chi-square test or Fisher's exact test was used for categorical variables. The survival difference was assessed by the log rank tests and Kaplan-Meier curves. A p-value <0.05 was considered statistically significant.

The effect of the age on the death or not after LT using univariate analysis and multivariate analysis were analysed. Typical factors associated with the death after LT were analysed by univariate analysis, and multivariate analysis was performed using 8 factors with p-value<0.1.


We retrospectively analyzed the data of 360 LT cases in Figure 1. Of these patients, 107 were excluded. Twenty-five patients were excluded due to repeated or additional surgery. Twenty patients were excluded as mental status could not be evaluated, while perioperative laboratory data were missing in 62 patients. Among the excluded patients, seven were aged 65 years or more: one patient was excluded due to repeated surgery, and six patients were excluded due to missing perioperative blood coagulation test data.

The preoperative characteristics of the patients are summarized in Table 1. The patients were divided into two groups: those aged<65 years (group Y, n=231) and those aged65 years (group O, n=22). The patients’ characteristics, such as body mass index (BMI), use of diuretics or insulin, use of psychiatric medication, and underlying diseases, were not significantly different between group Y and group O. Moreover, the reasons for LT and the Model for End-Stage Liver Disease (MELD) scores also showed no difference between the two groups.

Table 1.

Patients’ characteristics.

Characteristics  Group Y (n = 231)  Group O (n = 22)  p-valuea 
Age (y)  53 (22–64)  66 (65–74)  0.865 
Sex (M/F)  62 (26.84)/169 (73.16)  8 (36.36)/14 (63.64)  0.340 
Body mass index (kg.m−222.49±3.21  21.09±3.15  0.051 
LDLT/CDLT  153 (66.23)/78 (33.77)  11 (50)/11 (50)  0.635 
MELD score  18.32±11.29  20.00±9.93  0.500 
Cause for LT       
Alcoholic cirrhosis  50 (21.65)  3 (13.64)  0.294 
HBV and HCV  155 (67.10)  13 (59.09)   
NBNC LC  8 (3.46)  2 (9.09)   
Toxic hepatitis  13 (5.63)  3 (13.64)   
Primary biliary cirrhosis  5 (2.16)  1 (4.55)   
Ascites  76 (32.90)  10 (45.45)  0.235 
Hepatic Encephalopathy  37 (16.02)  5 (22.73)  0.381 
Varices  37 (16.02)  4 (18.18)  0.764 
HRS  20 (8.66)  3 (13.64)  0.433 
Hypertension  44 (19.05)  7 (31.82)  0.167 
Diabetes mellitus  61 (26.41)  5 (22.73)  0.707 
Ischemic heart disease  1 (0.43)  1 (4.55)  0.167 

Values are presented as mean (standard deviation), median (range) or number (%). SD, standard deviation; LDLT, living donor liver transplantation; CDLT, cadaveric donor liver transplantation; LT, liver transplantation; MELD, Model for End-Stage Liver Disease; HBV, hepatitis B virus; HCV, hepatitis C virus; NBNC LC, non-HBV non-HCV liver cirrhosis; HRS, hepatorenal syndrome; Group Y, patients<65 years; Group O, patients ≥ 65 years.


p<0.05 compared between groups.

In the preoperative laboratory findings, most of the results showed no difference between the two groups, except for hemoglobin (p=0.001), which was slightly lower in group O than in group Y (Table 2).

Table 2.

Perioperative laboratory data in patients undergoing liver transplantation.

Variables  Preoperative dataPostoperative data
  Group Y (n = 231)  Group O (n = 22)  p-valuea  Group Y (n = 231)  Group O (n = 22)  p-valuea 
Hb (g.dL−110.88±2.29  9.65±1.42  0.001a  8.93±1.49  9.25±1.31  0.331 
Bilirubin (μmol.L−12.70 (1.30–1.80)  3.30 (1.80–7.00)  0.253  4.00 (2.10–6.80)  4.90 (3.00–7.50)  0.307 
Protein (g.dL−15.97±0.87  5.66±0.84  0.108  5.27±0.69  5.17±0.55  0.470 
Albumin (g.dL−13.13±0.56  3.04±0.50  0.446  3.64±0.46  3.61±0.39  0.731 
K (mmol.L−13.98±0.54  3.95±0.61  0.817  3.99±0.41  4.12±0.49  0.166 
Cr (mg.dL−10.78 (0.61–1.00)  0.90 (0.77–1.19)  0.099  1.04±0.47  1.26±0.54  0.044a 
PT (INR)  1.55 (1.24–2.20)  1.75 (1.40–2.31)  0.203  1.79±0.37  1.67±0.30  0.139 

Values are expressed as mean±standard deviation or median (25th–75th percentile). Hb, hemoglobin; K, potassium; Cr, creatinine; PT, prothrombin time; INR, international normalized ratio; Group Y, patients<65 years; Group O, patients ≥ 65 years.


p<0.05 compared between groups.

During the surgery, patients in group O had a longer anesthetic duration than patients in group Y (p=0.033). In addition, the intraoperative estimated blood loss was higher in group O than in group Y (p=0.027). The total amounts of infused fluid (p=0.042) and packed red blood cells (p=0.008) were higher in group O than in group Y (Table 3).

Table 3.

Patients’ perioperative factors.

Variables  Group Y (n = 231)  Group O (n = 22)  p-valuea 
Anesthetic duration (h)  10.75 (9.20–12.50)  10.00 (8.50–11.00)  0.033a 
Intraoperative EBL (L)  2.80 (1.50–5.00)  4.00 (2.50–6.00)  0.027a 
Total fluid (L)  7.06 (5.32–10.09)  9.42 (6.40–13.26)  0.042a 
pRBC (units)  4.00 (0.00–10.00)  7.00 (4.00–12.00)  0.008a 
FFP (units)  4.00 (0.00–10.00)  6.50 (4.00–12.00)  0.076 
Cryo (units)  0.00 (0.00–0.00)  0.00 (0.00–0.00)  0.330 
PLT (units)  0.00 (0.00–0.00)  0.00 (0.00–8.00)  0.257 

EBL, estimated blood loss; pRBC, packed red blood cells; FFP, fresh frozen plasma; PLT, platelet; Group Y, patients<65 years; Group O, patients ≥ 65 years. Values are expressed as mean±standard deviation or median (25th–75th percentile).


p<0.05 compared between groups.

No notable differences in postoperative data were found between the two groups except for creatinine level. The plasma creatinine level after LT was higher in group O than in group Y (Table 4). However, there were no significant differences in the incidence of postoperative complications, including ICU stay and time from surgery to discharge.

Table 4.

Postoperative data of patients undergoing liver transplantation.

Variables  Group Y (n = 231)  Group O (n = 22)  p-valuea 
ICU stay (days)  8.00 (5.00–12.00)  14.00 (5.00–23.00)  0.112 
Time from surgery to discharge (days)  28.00 (22.00–42.00)  34.00 (22.00–70.00)  0.118 
Postoperative complication       
Cardiac complication  6 (2.60)  0 (0.00)  1.000 
Atrial fibrillation  5 (2.16)     
Infectious endocarditis  1 (0.43)     
Respiratory complication  19 (8.23)  3 (13.63)  1.000 
Neurologic complication       
Brain hemorrhage  0 (0.00)  1 (4.55)  0.087 
Seizure  1 (0.43)  0 (0.00)  1.000 
Brain injury  2 (0.87)  1 (4.55)  1.000 
Delirium  31 (13.42)  5 (22.73)  0.215 
Postoperative AKI  54 (23.38)  10 (45.45)  0.043a 
Infectious complication       
Abscess  3 (1.31)  1 (4.55)  1.000 
Sepsis  3 (1.31)  1 (4.55)  1.000 
Reoperation  20 (8.66)  5 (22.73)  0.060 
Acute rejection  6 (2.60)  0 (0.00)  1.000 
Death during hospitalization  10 (4.32)  2 (9.09)  0.879 

ICU, intensive care unit; AKI, acute kidney injury; Group Y, patients<65 years; Group O, patients ≥ 65 years. Values are expressed as number (%) or median (25th–75th percentile).


p<0.05 compared between groups.

Thirty-eight patients died after LT, five of whom were aged 65 years or older. In the group O, two patients died within 3 months of the liver transplant. One patient died of respiratory failure due to tuberculosis and the other died of multiple organ failure due to sepsis. In addition, there was no difference in the survival rate after liver transplantation depending on age using Kaplan-Meier curves (log-rank p-value=0.20) as depicted in Figure 2. In the univariate analysis in Table 5, LDLT or CDLT, hypertension, diabetes mellitus, alcoholic disease, ICU stay, cardiac complication, postoperative AKI showed lower p-values than 0.1. The multivariate analysis revealed that hypertension, diabetes mellitus were independent risk factors for death after LT (p<0.05). However, age (p=0.283) or groups classified by age (p=0.295) were not related with death after LT.

Figure 2.

Overall survival rate according to the follow-up period in O and Y groups. Group Y, patients<65 years; Group O, patients ≥ 65 years.

Table 5.

Logistic Regression Analysis for death after liver transplantation.

Variables  OR  95% CIp-value  OR  95% CI  p-value
    Lower  Upper      Lower  Upper   
Age  1.025  0.980  1.071  0.283         
Age (Group Y/O)  1.765  0.610  5.109  0.295         
Sex  0.928  0.433  1.990  0.848         
Body mass index  0.989  0.888  1.101  0.836         
LDLT/CDLT  2.670  1.325  5.383  0.006a  1.808  0.741  4.41  0.193 
Hypertension  2.422  1.137  5.160  0.022a  2.402  1.028  5.612  0.043b 
Diabetes mellitus  2.742  1.342  5.603  0.006a  2.497  1.145  5.443  0.021b 
Alcoholic cirrhosis  0.399  0.135  1.178  0.096a  0.309  0.096  0.999  0.050 
MELD score  1.009  0.979  1.040  0.545         
Anesthetic duration  1.072  0.965  1.191  0.197         
Intraoperative EBL  1.078  0.974  1.193  0.146         
Total fluid  1.032  0.978  1.088  0.256         
pRBC  1.014  0.981  1.049  0.409         
Hb after surgery  1.195  0.958  1.492  0.114         
Cr after surgery  1.911  1.020  3.581  0.043a  0.966  0.421  2.217  0.935 
ICU stay  1.064  1.031  1.098  < 0.001a  1.038  0.999  1.079  0.059 
Cardiac complication  6.057  1.175  31.218  0.031a  4.669  0.456  47.828  0.194 
Respiratory complication  1.765  0.610  5.109  0.295         
Postoperative AKI  2.209  1.071  4.559  0.032a  1.754  0.746  4.123  0.198 
Infection  1.910  0.193  18.859  0.580         
Reoperation  1.477  0.518  4.209  0.465         
Acute rejection  2.931  0.518  16.593  0.224         

OR, odds ratio; CI, confidence interval; CDLT, cadaveric donor liver transplantation; MELD, Model for End-Stage Liver Disease; Hb, hemoglobin; Cr, creatinine; EBL, estimated blood loss; pRBC, packed red blood cells; ICU, intensive care unit; AKI, acute kidney injury; Group Y, patients younger than 65 years; Group Y, patients<65 years; Group O, patients ≥ 65 years.


p<0.1 in univariate analysis.


p<0.05 in multivariate analysis.


As the number of elderly patients undergoing transplantation has increased, we analyzed the data on the occurrence of age-related complications in liver transplant recipients. Although the preoperative hemoglobin level was lower and the requirement for blood transfusion was more common in the elderly patients, there were no notable differences in postoperative complications, including ICU stay and time from surgery to discharge, between the two groups. In addition, there was no difference in survival rate after liver transplantation based on age.

Early studies have reported higher mortality rates in elderly recipients than in younger patients because more complications occurred after transplantation in elderly recipients even when the MELD score was the same between the 2 groups.5,6 The causes of high mortality in elderly recipients were as follows: comorbidities before surgery, malignancy, cardiovascular and/or neurological events after LT, renal failure, and secondary infections due to the use of immunosuppressants. The prognosis was poor in patients with renal insufficiency before surgery, especially in patients undergoing dialysis. Renal replacement therapy before surgery has been shown to have a strong association with poor outcomes.13 Furthermore, the rate of bacterial or fungal infection, post-transplantation sepsis, and the duration of ICU stay also increased in recipients with renal insufficiency before surgery.14 The second most influential comorbidity was cardiovascular diseases such as coronary artery disease, atherosclerosis in major vessels, and arrhythmia.11 Niazi et al.15 reported the impact of psychosocial factors on the outcomes associated with LT. Depression and anxiety are known to be related to poor outcomes after LT. In addition to these general complications, it was reported that elderly recipients had increased resource utilization owing to weak pulmonary function and low life expectancy.9,11 Thus, many authors recommend screening elderly recipients with associated comorbidities and malignancy and performing LT only in elderly patients without significant comorbid conditions.16–18

Recently, with accumulated experience and successful LT cases, several studies have reported that graft survival and mortality did not differ significantly between young and elderly liver transplant recipients.7,15,19–21 These studies suggested that functional status rather than chronological age had a greater impact on outcomes. Functional status depends not only on advanced patient age but also on behavioral factors, including exercise, BMI, smoking and alcohol use, and psychosocial factors. Moreover, regardless of age, high MELD scores, alcoholic liver disease, and medical comorbidities such as congestive heart failure, coronary artery disease, and renal insufficiency requiring dialysis were significantly associated with poor outcomes in liver transplant recipients.11 Furthermore, the utilization of medical resources after transplantation was similar in the two groups.22 However, those studies had limitations. They found that elderly liver transplant recipients had lower MELD scores, lower BMI, fewer comorbidities, and higher serum albumin than younger recipients. This shows that elderly patients with relatively preserved physiological conditions and low MELD scores selectively underwent LT.23

Blood transfusions are one of the known causes of postoperative complications such as infection, respiratory complications, myocardial infarction, and renal insufficiency.24,25 Our study showed that group O had lower preoperative hemoglobin and more intraoperative transfusions than group Y. Blood transfusions are known to affect postoperative complications by directly increasing the plasma concentration of inflammatory mediators26 and amplifying the inflammatory response induced by surgery.27 However, our study showed that although there were differences in transfusion doses, there was no difference in the incidence of complications. Similar results have been obtained in other studies. Postoperative complications were reduced by the use of red blood cells that were irradiated or depleted of leukocytes by filtration during surgery.28–31

In our study, there was no significant difference in the occurrence of complications after LT between group O and group Y, and the patient characteristics, preoperative laboratory findings except for hemoglobin level, and comorbidities also did not differ significantly. The total amounts of infused fluid and packed red blood cells were higher, and the postoperative creatinine level was higher in the elderly group than in the younger group; however, there was no significant difference in the incidence of acute kidney injury after transplantation. Moreover, the ICU length of stay and time from surgery to discharge also showed no notable differences between the two groups. Altogether, these findings suggest that elderly patients may be considered adequate candidates for LT.

There are several risk factors for mortality after LT. Dialysis patients are known to have the highest risk of death regardless of age, and the number of fresh frozen plasma units transfused and re-transplantation have a statistically significant association with early death due to sepsis.9,32 Previous studies have indicated that the risk of mortality is increased in liver transplant recipients aged ≥ 60 years-old, especially patients undergoing renal replacement therapy.9,32 However, our study failed to demonstrate any association of advanced age and an increased mortality rate. Although this study has shown that the elderly group had a higher incidence of AKI after LT, serum creatinine levels were similar in both groups after surgery and any clinical difference between groups seems to be negligible.

This study has important limitations. The number of patients aged ≥ 65 years was small (22 patients); therefore, the outcomes of postoperative complications in elderly patients cannot be considered completely similar to those in younger patients. Because of the small number of “exposed” patients, the probability of type 2 error cannot be ignored, and the findings may not be sufficient to conclude that LT is safe in elderly patients.

Second, our study did not investigate long-term prognosis. It is an important issue that elderly recipients have a relatively short life expectancy and may have other critical diseases compared with younger patients, regardless of the severity of liver function before transplantation. Thus, long-term follow-up is necessary for a more accurate comparison between young and old patients.

Another limitation is our inability to collect data on vascular and biliary complications since the relevant data were missing. Vascular and biliary tract complications are known to be common in elderly patients,33 increasing the risk of type 2 error in relation to the mortality rate.

In conclusion, despite the limitations imposed by the small number of patients, our study has demonstrated positive results for the safety indication of LT in elderly patients. Therefore, to improve the prognosis of elderly patients who require LT in the future, it is necessary to focus on the main strategies and new protocols in order to identify potential risk factors, and improve outcomes in elderly patients undergoing liver transplantation.

Conflict of interest

The authors declare no conflicts of interest.


This study was supported by the Research Institute for Convergence of Biomedical Science and Technology Grant (30-2018-012), Pusan National University Yangsan Hospital. This work was supported by the Department of Biostatistics, Clinical Trial Center, Biomedical Research Institute, Pusan National University Hospital.

L.S. Yang, L.L. Shan, A. Saxena, et al.
Liver transplantation: a systematic review of long-term quality of life.
Liver Int., 34 (2014), pp. 1298-1313
E.B. Keeffe.
Liver transplantation: current status and novel approaches to liver replacement.
Gastroenterology., 120 (2001), pp. 749-762
A.S. Yu, A. Ahmed, E.B. Keeffe.
Liver transplantation: evolving patient selection criteria.
Can J Gastroenterol., 15 (2001), pp. 729-738
B.H. Collins, J.D. Pirsch, Y.T. Becker, et al.
Long-term results of liver transplantation in older patients 60 years of age and older.
Transplantation., 70 (2000), pp. 780-783
J. Showstack, P.P. Katz, J.R. Lake, et al.
Resource utilization in liver transplantation: effects of patient characteristics and clinical practice.
NIDDK Liver Transplantation Database Group. JAMA., 281 (1999), pp. 1381-1386
C.L. Berg, D.E. Steffick, E.B. Edwards, et al.
Liver and intestine transplantation in the United States 1998-2007.
Am J Transplant., 9 (2009), pp. 907-931
A.I. Sutherland, J.N. IJzermans, J.L. Forsythe, et al.
Kidney and liver transplantation in the elderly.
Br J Surg., 103 (2016), pp. e62-e72
H.Y. Li, Y.G. Wei, L.N. Yan, et al.
Outcomes Between Elderly and Young Hepatocellular Carcinoma Living Donor Liver Transplantation Recipients: A Single-Center Experience.
Medicine (Baltimore)., 95 (2016), pp. e2499
H.P. Chen, Y.F. Tsai, J.R. Lin, et al.
Recipient Age and Mortality Risk after Liver Transplantation: A Population-Based Cohort Study.
PLoS One., 11 (2016), pp. e0152324
A. Akdur, C. Fidan, E. Ayvazoglu Soy, et al.
Results of liver transplant in elderly patients: a single center experience.
Exp Clin Transplant., 13 (2015), pp. 124-126
A. Sonny, D. Kelly, J.P. Hammel, et al.
Predictors of poor outcome among older liver transplant recipients.
Clin Transplant., 29 (2015), pp. 197-203
R.L. Mehta, J.A. Kellum, S.V. Shah, et al.
Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury.
Crit Care., 11 (2007), pp. R31
G. Contreras, G. Garces, A.A. Quartin, et al.
An epidemiologic study of early renal replacement therapy after orthotopic liver transplantation.
J Am Soc Nephrol., 13 (2002), pp. 228-233
M.S. Campbell, D.S. Kotlyar, C.M. Brensinger, et al.
Renal function after orthotopic liver transplantation is predicted by duration of pretransplantation creatinine elevation.
Liver Transpl., 11 (2005), pp. 1048-1055
S. Niazi, T. Schneekloth, C.B. Taner.
Elderly recipients of liver transplantation: impact of age and psychosocial variables on outcome.
Curr Opin Organ Transplant., 22 (2017), pp. 588-592
R.N. Keswani, A. Ahmed, E.B. Keeffe.
Older age and liver transplantation: a review.
Liver Transpl., 10 (2004), pp. 957-967
S.H. Yi, H.M. Yi, B.S. Fu, et al.
Long-term results of liver transplantation for over 60 years old patients with hepatitis B virus-related end-stage liver disease.
Hepatobiliary Pancreat Dis Int., 13 (2014), pp. 501-507
E. Slattery, J.E. Hegarty, P.A. McCormick.
It's a man's world: does orthotopic liver transplantation in the elderly male confer an additional risk on survival?.
Can J Gastroenterol., 26 (2012), pp. 697-700
H. Ushigome, T. Nakao, S. Harada, et al.
Elderly living donor liver transplant recipients over 60 Years old at a japanese single center.
Transplant Proc., 48 (2016), pp. 1115-1118
T. Shimagaki, T. Yoshizumi, K. Kimura, et al.
Living Donor Liver Transplantation in an Elderly Recipient with Preserved Performance Status: A Case Report.
Fukuoka Igaku Zasshi., 107 (2016), pp. 115-120
K.P. Croome, D.D. Lee, J.M. Burns, et al.
Simultaneous liver and kidney transplantation in elderly patients: Outcomes and validation of a clinical risk score for patient selection.
Ann Hepatol., 15 (2016), pp. 870-880
G.C. Wilson, R.C. Quillin 3rd, K. Wima, et al.
Is liver transplantation safe and effective in elderly (>/=70 years) recipients?. A case-controlled analysis.
HPB (Oxford)., 16 (2014), pp. 1088-1094
J.J. Schwartz, L. Pappas, H.F. Thiesset, et al.
Liver transplantation in septuagenarians receiving model for end-stage liver disease exception points for hepatocellular carcinoma: the national experience.
Liver Transpl., 18 (2012), pp. 423-433
B.L. Ecker, K.D. Simmons, S. Zaheer, et al.
Blood Transfusion in Major Abdominal Surgery for Malignant Tumors: A Trend Analysis Using the National Surgical Quality Improvement Program.
JAMA Surg., 151 (2016), pp. 518-525
M.T. de Boer, M.C. Christensen, M. Asmussen, et al.
The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation.
Anesth Analg., 106 (2008), pp. 32-44
A. Avall, M. Hyllner, J.P. Bengtson, et al.
Postoperative inflammatory response after autologous and allogeneic blood transfusion.
Anesthesiology., 87 (1997), pp. 511-516
E. Fransen, J. Maessen, M. Dentener, et al.
Impact of blood transfusions on inflammatory mediator release in patients undergoing cardiac surgery.
Chest., 116 (1999), pp. 1233-1239
R.W. Chu.
Leukocytes in blood transfusion: adverse effects and their prevention.
Hong Kong Med J., 5 (1999), pp. 280-284
G.N. Tzimas, M. Deschenes, J.S. Barkun, et al.
Leukoreduction and acute rejection in liver transplantation: an interim analysis.
Transplant Proc., 36 (2004), pp. 1760-1762
A.B. Narvios, M. de Lima, H. Shah, et al.
Transfusion of leukoreduced cellular blood components from cytomegalovirus-unscreened donors in allogeneic hematopoietic transplant recipients: analysis of 72 recipients.
Bone Marrow Transplantation., 36 (2005), pp. 499-501
L.M. van de Watering, J. Hermans, J.G. Houbiers, et al.
Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery: a randomized clinical trial.
Circulation., 97 (1998), pp. 562-568
T.J. Cross, C.G. Antoniades, P. Muiesan, et al.
Liver transplantation in patients over 60 and 65 years: an evaluation of long-term outcomes and survival.
Liver Transpl., 13 (2007), pp. 1382-1388
J.H. Han, Y.K. You, G.H. Na, et al.
Outcomes of living donor liver transplantation using elderly donors.
Ann Surg Treat Res., 86 (2014), pp. 184-191
Copyright © 2021. Sociedade Brasileira de Anestesiologia
Brazilian Journal of Anesthesiology (English Edition)

Subscribe to our newsletter

Article options